Polygot is a combination drug. Ergotamine is a natural ergot alkaloid, increases the tone of dilated extracranial arteries, affects serotonin receptors. Caffeine accelerates and increases the absorption of ergotamine. Polygot is an antimigraine agent. After oral administration, about 62% of ergotamine is absorbed in the gastrointestinal tract . Maximum plasma concentrations are reached 2 hours after oral administration. Binding to plasma proteins is 98%. Ergotamine is metabolized in the liver to form pharmacologically active metabolites. Ergotamine is excreted mainly with bile both unchanged and as metabolites. Excretion is biphasic, with half-lives of 2.7 hours and 21 hours for I and II phases, respectively. After oral administration caffeine is absorbed quickly and almost completely. Binding with plasma proteins is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly with urine. Half-life period is about 3.5 hours.
Indications for use. Headache of vascular genesis (including migraine).
Contraindications. Hypersensitivity, peripheral arterial occlusive disease, CHD, arterial hypertension, hepatic insufficiency, chronic liver failure, sepsis, pregnancy and lactation.
How to use: the dosage and treatment
Inside. It is taken at the beginning of attacks 2 tablets; if necessary, 1 tablet at 30-minute intervals until the condition improves, not exceeding the maximum daily dose (6 tablets). The maximum weekly dose is 10 tablets. In subsequent attacks, the initial dose is increased to 3 tablets, depending on the total dose taken during the previous attacks.
Nausea, vomiting, allergic reactions, increased BP. During long-term use, weakness and pain in the extremities, tremor, cardialgia, tachycardia, bradycardia, fibrotic changes in the pleura and retroperitoneal space.
Overdose. Symptoms: drowsiness, confusion, tachycardia, dizziness, paresthesia, respiratory center depression, coma. Treatment: gastric lavage, activated charcoal, symptomatic therapy.
Special indications. It is not used for prophylaxis of migraine attacks.
Interaction. Macrolides increase the concentration of ergotamine.
Alpha-adrenergic stimulants, propranolol, nicotine increase the vasoconstrictor effect. Concomitant administration of oleandomycin, erythromycin, or josamycin together with ergotamine may lead to increased plasma concentrations of ergotamine. Several cases of vasospasm have been reported in patients receiving ergotamine and propranololol simultaneously.
The above information is intended for medical and pharmaceutical specialists. The most precise information about the drug is given in the instructions accompanying the package by the manufacturer. No information given on this or any other page of our website should be used as a substitute for consulting a physician in person.